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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling

Fig. 2

BM-MSC and exosome transplantation alleviates bone loss induced by irradiation. a HE staining of rat left tibia in each group. b 3D micro-CT image of the target region (a region below the growth plate from 2.0 to 4.0 mm). c Bone microarchitecture analysis of target region in the proximal of left tibia. Abbreviations: BV/TV, bone volume to total tissue volume ratio; BMD, bone mineral density; Conn. D, connective density; Tb. N, trabecular number; Tb. Th, trabecular thickness. Data represent the mean ± SD (n = 5 independent experiments, t test).*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Abbreviations: day 0, rats with no treatment and sacrificed on day 0; day 28, rats with no treatment and sacrificed on day 28; R day 28, rats received 16 Gy irradiation on day 0 and sacrificed on day 28; R+MSCT day28, rats received 16 Gy irradiation and MSC transplantation and sacrificed on day 28; R+Ex day 28, rats received 16 Gy irradiation and exosome transplantation and sacrificed on day 28

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