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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling

Fig. 3

Exosomes alleviate radiation-induced oxidative stress in BM-MSCs. a ROS production in irradiated and exosomes cocultured with BM-MSCs were detected by DCF fluorescence after 24 h. b ROS levels were assessed by DCF fluorescence intensity via flow cytometry. Relative DCF fluorescent values revealed reduced ROS production in exosomes cocultured with BM-MSCs. c Quantitative analysis of fluorescence intensity. Data are presented as the mean ± SD. **p < 0.01. d Western blot analysis of antioxidant protein catalase, SOD2, and SOD1. Abbreviations: 6 Gy, BM-MSCs received 6 Gy gamma irradiation; 6 Gy+Ex, BM-MSCs received 6 Gy gamma irradiation then cocultured with 100 μg/ml exosomes

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Stem Cell Research & Therapy

ISSN: 1757-6512