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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis

Fig. 4

CCl4-induced chronic hepatic fibrosis was significantly attenuated by iHEPs transplantation in BALB/C nude mouse. a Representative of gross finding of the liver in chronic hepatic fibrosis model by intra-peritoneal CCl4 injections for 10 weeks. A total of 1 × 106 iHEPs (type A or type B) or DMEM only were transplanted through intra-splenic injection. Left to right: olive oil, CCl4, CCl4 + iHEPs (type A), and CCl4 + iHEPs (type B), respectively. b Serum levels of AST and ALT after 10 weeks of CCl4 injections in chronic hepatic fibrosis model (***P < 0.0001)

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