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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Stem cells from human exfoliated deciduous teeth correct the immune imbalance of allergic rhinitis via Treg cells in vivo and in vitro

Fig. 4

Expression of mRNAs encoding cytokines and specific transcription factors. The relative mRNA expression levels of IL-4 and GATA-3 were significantly higher in the OVA group than in the control and sham-SHED groups, and such upregulation was inhibited by SHED and BMMSC administration. The IFN-γ, T-bet, and Foxp3 mRNA expression levels were markedly enhanced by SHED and BMMSC administration. In addition, MSCs reduced the mRNA expression of IL-17A, but RORγt expression in the SHED and BMMSC treatment groups had no significant change compared with that in the OVA group. The capacity of SHEDs in reducing IL-4 and GATA-3 levels was superior to that of BMMSCs. Data are expressed as the mean ± SD (n = 6 in each group) from three representative experiments. *p < .05, **p < .01, ***p < .001, n.s. no significance

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Stem Cell Research & Therapy

ISSN: 1757-6512