Fig. 4

SVF-gel restores normal cutaneous structures in hypertrophic scars. a H&E staining showed that skin had a normal structure with a complete epidermis, a thinner dermal layer, and substantial subcutaneous fat tissue in the SVF-gel-treated group. However, little subcutaneous fat tissue was observed in the PBS- and SVF cell-treated groups. Scale bars = 500 μm. b Restoration of subcutaneous fat tissue in the SVF-gel-treated group was confirmed by immunofluorescence staining of perilipin. Scale bar = 200 μm. c At week 12, dermal thickness was reduced most by treatment with SVF-gel (SVF-gel, 0.50 ± 0.25 mm; PBS, 1.38 ± 0.32 mm; *p < 0.05) and was also decreased by treatment with SVF cells (SVF cells, 1.04 ± 0.32 mm, *p < 0.05)