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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mechanical micronization of lipoaspirates for the treatment of hypertrophic scars

Fig. 6

SVF-gel reduces the fibrotic tendency in hypertrophic scars. a (Upper) MT staining of the 12-week samples showed that collagen fibers were dense and irregularly arranged in the PBS-treated group. Collagen deposition was reduced and collagen fibers were well-arranged in the SVF-gel- and SVF cell-treated groups. a (Lower) Immunostaining of α-SMA of the 12-week samples showed that myofibroblasts (black arrows) were present in the dermal layer. b At week 12, quantification of collagen density showed that PBS-treated group had the highest collagen density, while collagen density was significantly reduced in SVF-gel group (p < 0.05). c Quantification of myofibroblasts in scars showed that myofibroblast infiltration was lowest in the SVF-gel-treated group at week 12 (*p < 0.05). d Quantitative reverse transcription PCR of Col-1 expression in scars in the three groups. No significant difference was observed among the three groups at week 1. Col-1 expression was lower in the SVF-gel-treated group than in the PBS- and SVF cell-treated groups since week 4 (*p < 0.05)

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