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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

Fig. 6

Effect of ASC-MVs on wound healing in mice. a Gross view of excisional wounds in mice treated with either 50 μg ASC-MVs or an equal volume of PBS at different time points (n = 9). b Measurement of wound areas shown in a. c H&E staining analysis of wound sections following different treatments at day 13 post-wounding. The single-headed arrows indicate the un-epithelialized areas. The double-headed arrows indicate the edges of the granulation. Scar bar, 1 mm. d Qualification of wound re-epithelialization shown in c. e Qualification of granulation tissue formation shown in c. f Evaluation of collagen deposition by Masson staining at day 13 post-wounding. g Qualification of the stain intensity of blue collagen shown in f. h Qualification of the ratio of PCNA+ cells in wound beds. i Immunohistochemical staining for PCNA expression in wound sections. Scar bar, 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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