Fig. 8
Regulation of macrophage cytokine secretion by MSC loaded in HG. a Scheme of MSC treatment with CM and cell culture in HG (upper row). Scheme of macrophage culture on HG loaded with MSC primed or not with CM (middle row) or cultured on HG lacking MSC (lower row). b Images of MΦGM or MΦM cultured on TCP or HG and of unprimed MSC cultured on TCP or encapsulated in HG. c Ratio between IL-10 and TNF-α levels in media of MΦGM or MΦM cultured on TCP or HG. d PGE2 levels in media of MSC primed or not with CM and cultured on TCP or encapsulated in HG. PGE2, TNF-α and IL-10 levels in media of MΦGM (e) or MΦM (f) cultured on empty HG or on HG loaded with MSC primed or not with CM. *p < 0.05