From: Mesenchymal stem/stromal cell function in modulating cell death
Studies | Sources of MSCs | MSC death modulation function | Modes of actions | References |
---|---|---|---|---|
Preclinical in vitro and in vivo | Human BM-MSCs | Apoptosis in human primary CD34+ cells induced by γ-irradiation with xenotransplantation in a baboon model | Not determined | Drouet et al. [42] |
Preclinical in vitro | Human BM-MSCs | Activation-induced cell death, apoptosis induced by anti-CD3 Abs, or deprivation of serum or anti-Fas Abs in primary human thymocytes and human Jurkat T cell line | Fas-FasL pathway inhibition | Benvenuto et al. [39] |
Preclinical in vitro | Human BM-MSCs | Apoptosis in human primary neutrophils induced by IL-8, or in resting state | IL-6, STAT3 | Raffaghello et al. [58] |
Preclinical in vitro | Rat BM-MSCs | Apoptosis in Rat PC12 neuron cell line and rat primary cortical neurons induced by deprivation of serum and exposure to EtOH | PI3K/Akt, ERK1/2 | Liu et al. [45] |
Preclinical in vitro | Mouse and human BM-MSCs | Apoptosis and/or necroptosis induced in rat PC12 neuron cell line, human ReNcell CX neural progenitor cell line, and rat cortical primary neurons induced by 6-OHDA | Prosaposin | Li et al. [65] |
Preclinical in vitro | Human UC-MSCs | Apoptosis in human primary neutrophils induced by deprivation of serum | Not determined | Maqbool et al. [47] |
Preclinical in vitro | Rat BM-MSCs | Apoptosis in human SH-SY5Y neuroblastoma cell line induced by misfolded tau protein | Not determined | Zilka et al. [56] |
Preclinical in vitro | Mouse and human BM-MSCs | Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen | PI3K/Akt, STAT3 | Scheibe et al. [50] |
Preclinical in vivo | Rat BMMSCs | Apoptosis in rat lung fibroblasts induced by cigarette smoke extract | PI3K/Akt and Caspase-3 inhibition | Kim et al. [64] |
Preclinical in vitro and in vivo | Rat BM-MSCs | Apoptosis in rat INS-1 pancreatic cell line induced by high glucose exposure and in pancreatic β cells in STZ induced type 2 DM in Rat | Not determined | Zhao et al. [54] |
Clinical | Human BM-MSCs | Apoptosis and necrosis in alveolar epithelial cells in patients with ARDS | Immunosuppressive and/or trophic factors and/or EVs | Simonson et al. [63] |
Preclinical in vitro | Human BM-MSCs | Pyroptosis in human THP-1 monocytic cell line and mouse MH-S alveolar macrophage cell line induced by nanoparticles | IL-10 | Naji et al. [48] |
Preclinical in vitro | Rat BM-MSCs | Apoptosis and necroptosis in mouse primary cortical neurons induced by deprivation of glucose and oxygen | Caspase-3 and RIP-1/3 inhibition | Kong et al. [57] |
Preclinical in vivo | Mouse BM-MSCs | Pyroptosis in mouse hepatocyte induced by d-galactosamine acute liver injury in a mouse model | IL-10 | Wang et al. [61] |
Preclinical in vitro and in vivo | Rat BM-MSCs | Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen and in rat cortical neurons induced by ischemia with right carotid artery ligation and exposure to hypoxia in a rat model | BDNF, mTOR | Zheng et al. [55] |