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Table 1 Mesenchymal stem/stromal cell (MSC) death modulation function depending on paracrine factors and/or other modes of actions

From: Mesenchymal stem/stromal cell function in modulating cell death

Studies

Sources of MSCs

MSC death modulation function

Modes of actions

References

Preclinical in vitro and in vivo

Human BM-MSCs

Apoptosis in human primary CD34+ cells induced by γ-irradiation with xenotransplantation in a baboon model

Not determined

Drouet et al. [42]

Preclinical in vitro

Human BM-MSCs

Activation-induced cell death, apoptosis induced by anti-CD3 Abs, or deprivation of serum or anti-Fas Abs in primary human thymocytes and human Jurkat T cell line

Fas-FasL pathway inhibition

Benvenuto et al. [39]

Preclinical in vitro

Human BM-MSCs

Apoptosis in human primary neutrophils induced by IL-8, or in resting state

IL-6, STAT3

Raffaghello et al. [58]

Preclinical in vitro

Rat BM-MSCs

Apoptosis in Rat PC12 neuron cell line and rat primary cortical neurons induced by deprivation of serum and exposure to EtOH

PI3K/Akt, ERK1/2

Liu et al. [45]

Preclinical in vitro

Mouse and human BM-MSCs

Apoptosis and/or necroptosis induced in rat PC12 neuron cell line, human ReNcell CX neural progenitor cell line, and rat cortical primary neurons induced by 6-OHDA

Prosaposin

Li et al. [65]

Preclinical in vitro

Human UC-MSCs

Apoptosis in human primary neutrophils induced by deprivation of serum

Not determined

Maqbool et al. [47]

Preclinical in vitro

Rat BM-MSCs

Apoptosis in human SH-SY5Y neuroblastoma cell line induced by misfolded tau protein

Not determined

Zilka et al. [56]

Preclinical in vitro

Mouse and human BM-MSCs

Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen

PI3K/Akt, STAT3

Scheibe et al. [50]

Preclinical in vivo

Rat BMMSCs

Apoptosis in rat lung fibroblasts induced by cigarette smoke extract

PI3K/Akt and Caspase-3 inhibition

Kim et al. [64]

Preclinical in vitro and in vivo

Rat BM-MSCs

Apoptosis in rat INS-1 pancreatic cell line induced by high glucose exposure and in pancreatic β cells in STZ induced type 2 DM in Rat

Not determined

Zhao et al. [54]

Clinical

Human BM-MSCs

Apoptosis and necrosis in alveolar epithelial cells in patients with ARDS

Immunosuppressive and/or trophic factors and/or EVs

Simonson et al. [63]

Preclinical in vitro

Human BM-MSCs

Pyroptosis in human THP-1 monocytic cell line and mouse MH-S alveolar macrophage cell line induced by nanoparticles

IL-10

Naji et al. [48]

Preclinical in vitro

Rat BM-MSCs

Apoptosis and necroptosis in mouse primary cortical neurons induced by deprivation of glucose and oxygen

Caspase-3 and RIP-1/3 inhibition

Kong et al. [57]

Preclinical in vivo

Mouse BM-MSCs

Pyroptosis in mouse hepatocyte induced by d-galactosamine acute liver injury in a mouse model

IL-10

Wang et al. [61]

Preclinical in vitro and in vivo

Rat BM-MSCs

Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen and in rat cortical neurons induced by ischemia with right carotid artery ligation and exposure to hypoxia in a rat model

BDNF, mTOR

Zheng et al. [55]

  1. This table is representative but not exhaustive. Although the table recapitulates studies on MSC death modulation function depending on paracrine factors, this does not exclude the implication of other modes of actions. Studies are ordered from the oldest to the most recent. BM-MSCs, bone marrow mesenchymal stem/stromal cells; UC-MSCs, umbilical cord mesenchymal stem/stromal cells; CD, cluster of differentiation; IL, interleukin; EtOH, ethanol; OHDA, hydroxydopamine; STZ, streptozotocin; RIP, receptor-interacting protein; BDNF, brain-derived neurotrophic factor; mTOR, mammalian target of rapamycin