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Table 1 Mesenchymal stem/stromal cell (MSC) death modulation function depending on paracrine factors and/or other modes of actions

From: Mesenchymal stem/stromal cell function in modulating cell death

Studies Sources of MSCs MSC death modulation function Modes of actions References
Preclinical in vitro and in vivo Human BM-MSCs Apoptosis in human primary CD34+ cells induced by γ-irradiation with xenotransplantation in a baboon model Not determined Drouet et al. [42]
Preclinical in vitro Human BM-MSCs Activation-induced cell death, apoptosis induced by anti-CD3 Abs, or deprivation of serum or anti-Fas Abs in primary human thymocytes and human Jurkat T cell line Fas-FasL pathway inhibition Benvenuto et al. [39]
Preclinical in vitro Human BM-MSCs Apoptosis in human primary neutrophils induced by IL-8, or in resting state IL-6, STAT3 Raffaghello et al. [58]
Preclinical in vitro Rat BM-MSCs Apoptosis in Rat PC12 neuron cell line and rat primary cortical neurons induced by deprivation of serum and exposure to EtOH PI3K/Akt, ERK1/2 Liu et al. [45]
Preclinical in vitro Mouse and human BM-MSCs Apoptosis and/or necroptosis induced in rat PC12 neuron cell line, human ReNcell CX neural progenitor cell line, and rat cortical primary neurons induced by 6-OHDA Prosaposin Li et al. [65]
Preclinical in vitro Human UC-MSCs Apoptosis in human primary neutrophils induced by deprivation of serum Not determined Maqbool et al. [47]
Preclinical in vitro Rat BM-MSCs Apoptosis in human SH-SY5Y neuroblastoma cell line induced by misfolded tau protein Not determined Zilka et al. [56]
Preclinical in vitro Mouse and human BM-MSCs Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen PI3K/Akt, STAT3 Scheibe et al. [50]
Preclinical in vivo Rat BMMSCs Apoptosis in rat lung fibroblasts induced by cigarette smoke extract PI3K/Akt and Caspase-3 inhibition Kim et al. [64]
Preclinical in vitro and in vivo Rat BM-MSCs Apoptosis in rat INS-1 pancreatic cell line induced by high glucose exposure and in pancreatic β cells in STZ induced type 2 DM in Rat Not determined Zhao et al. [54]
Clinical Human BM-MSCs Apoptosis and necrosis in alveolar epithelial cells in patients with ARDS Immunosuppressive and/or trophic factors and/or EVs Simonson et al. [63]
Preclinical in vitro Human BM-MSCs Pyroptosis in human THP-1 monocytic cell line and mouse MH-S alveolar macrophage cell line induced by nanoparticles IL-10 Naji et al. [48]
Preclinical in vitro Rat BM-MSCs Apoptosis and necroptosis in mouse primary cortical neurons induced by deprivation of glucose and oxygen Caspase-3 and RIP-1/3 inhibition Kong et al. [57]
Preclinical in vivo Mouse BM-MSCs Pyroptosis in mouse hepatocyte induced by d-galactosamine acute liver injury in a mouse model IL-10 Wang et al. [61]
Preclinical in vitro and in vivo Rat BM-MSCs Apoptosis in rat primary cortical neurons induced by deprivation of glucose and oxygen and in rat cortical neurons induced by ischemia with right carotid artery ligation and exposure to hypoxia in a rat model BDNF, mTOR Zheng et al. [55]
  1. This table is representative but not exhaustive. Although the table recapitulates studies on MSC death modulation function depending on paracrine factors, this does not exclude the implication of other modes of actions. Studies are ordered from the oldest to the most recent. BM-MSCs, bone marrow mesenchymal stem/stromal cells; UC-MSCs, umbilical cord mesenchymal stem/stromal cells; CD, cluster of differentiation; IL, interleukin; EtOH, ethanol; OHDA, hydroxydopamine; STZ, streptozotocin; RIP, receptor-interacting protein; BDNF, brain-derived neurotrophic factor; mTOR, mammalian target of rapamycin