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Table 2 Mesenchymal stem/stromal cell (MSC) death modulation function depending on gap junctions

From: Mesenchymal stem/stromal cell function in modulating cell death

Studies Sources of MSCs MSC death modulation function Modes of actions References
Preclinical in vitro Mouse BM-MSCs Apoptosis in rat H9c2 cardiomyoblast cell line induced by deprivation of glucose and oxygen Cxs and/or TNTs Cselenyak [41]
Preclinical in vitro and in vivo Rat BM-MSCs Apoptosis in rat MSCs induced by deprivation of oxygen and in mouse cardiomyocytes in a myocardial infarction mouse model induced by LAD artery ligation Cx-43 Wang et al. [67]
Preclinical in vitro and in vivo Mouse and human BM-MSCs Apoptosis in human and mouse primary CD34+ cells in vitro, and in vivo in a mouse model of bone marrow transplantation Cx-43, Cx-45, CXCL12 Schajnovitz et al. [60]
Preclinical in vivo Mouse and human BM-MSCs Apoptosis in alveolar epithelial cells induced by LPS in vivo in an acute lung injury mouse model Cx-43, transfer of mitochondria via EVs and TNTs Islam et al. [43]
Preclinical in vitro Human BM-MSCs Apoptosis in human MM cell lines RPMI 8266, U266, XG-4, XG-7, and human primary MM cells Cx-43 Zhang et al. [68]
Preclinical in vitro Human BM-MSCs Apoptosis and/or necroptosis in human MM cell line RPMI 8266, U266, XG-7, and human primary MM cells induced by bortezomib Cx-43 Fu et al. [66]
  1. This table is representative but not exhaustive. Although the table recapitulates studies on MSC death modulation function depending on gap junctions, this does not exclude the implication of other modes of actions. Studies are ordered from the oldest to the most recent. BM-MSCs, bone marrow mesenchymal stem/stromal cells; Cxs, connexins; CXCL, CXC ligand; TNTs, tunneling nanotubes; LAD, left anterior descending; LPS, lipopolysaccharide; EVs, extracellular vesicles; MM, multiple myeloma