Table 2 Mesenchymal stem/stromal cell (MSC) death modulation function depending on gap junctions
From: Mesenchymal stem/stromal cell function in modulating cell death
Studies | Sources of MSCs | MSC death modulation function | Modes of actions | References |
|---|---|---|---|---|
Preclinical in vitro | Mouse BM-MSCs | Apoptosis in rat H9c2 cardiomyoblast cell line induced by deprivation of glucose and oxygen | Cxs and/or TNTs | Cselenyak [41] |
Preclinical in vitro and in vivo | Rat BM-MSCs | Apoptosis in rat MSCs induced by deprivation of oxygen and in mouse cardiomyocytes in a myocardial infarction mouse model induced by LAD artery ligation | Cx-43 | Wang et al. [67] |
Preclinical in vitro and in vivo | Mouse and human BM-MSCs | Apoptosis in human and mouse primary CD34+ cells in vitro, and in vivo in a mouse model of bone marrow transplantation | Cx-43, Cx-45, CXCL12 | Schajnovitz et al. [60] |
Preclinical in vivo | Mouse and human BM-MSCs | Apoptosis in alveolar epithelial cells induced by LPS in vivo in an acute lung injury mouse model | Cx-43, transfer of mitochondria via EVs and TNTs | Islam et al. [43] |
Preclinical in vitro | Human BM-MSCs | Apoptosis in human MM cell lines RPMI 8266, U266, XG-4, XG-7, and human primary MM cells | Cx-43 | Zhang et al. [68] |
Preclinical in vitro | Human BM-MSCs | Apoptosis and/or necroptosis in human MM cell line RPMI 8266, U266, XG-7, and human primary MM cells induced by bortezomib | Cx-43 | Fu et al. [66] |