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Table 3 Mesenchymal stem/stromal cell (MSC) death modulation function depending on tunneling nanotubes

From: Mesenchymal stem/stromal cell function in modulating cell death

Studies Sources of MSCs MSC death modulation function Modes of actions References
Preclinical in vitro Human BM-MSCs Apoptosis in human lung epithelial cell lines A549ρ0induced by ethidium bromide Transfer of mitochondria via EVs and TNTs or both Spees et al. [27]
Preclinical in vitro Mouse BM-MSCs Apoptosis in rat H9c2 cardiomyoblast cell line induced by deprivation of glucose and oxygen Cxs and/or TNTs Cselenyak [41]
Preclinical in vivo Mouse and human BM-MSCs Apoptosis in alveolar epithelial cells induced by LPS in vivo in an acute lung injury mouse model Cx-43, transfer of mitochondria via EVs and TNTs Islam et al. [43]
Preclinical in vitro Human BM-MSCs Apoptosis in human primary HUVEC induced by deprivation of oxygen Transfer of mitochondria via TNTs Liu et al. [44]
Preclinical in vitro and in vivo Human BM-MSCs Apoptosis in human primary bronchial epithelial cells and bronchial smooth muscle cells and human epithelial cell line BEAS-2B, A549 induced by rotenone. Apoptosis in mouse primary tracheal epithelial cells and mouse lung epithelial cell lines ML-12 and lung adenocarcinoma LA-4 induced by rotenone. Apoptosis in alveolar epithelial cells in lung injury mouse models induced by rotenone or an allergen Transfer of mitochondria via TNTs Ahmad et al. [38]
Preclinical in vitro Rat BM-MSCs Apoptosis in rat cardiomyoblast cell line H9c2 induced by deprivation of glucose and oxygen Transfer of mitochondria via TNTs Han et al. [69]
Preclinical in vitro and in vivo Human ASCs Apoptosis in human primary cardiomyocytes or endothelial cells induced by ethidium bromide, hydrogen peroxide, or doxorubicin. Apoptosis in mouse cardiomyocytes induced in a myocardial infarction mouse model with LAD artery ligation Transfer of mitochondria via EVs and/or TNTs, and Heme oxygenase Mahrouf-Yorgov et al. [46]
  1. This table is representative but not exhaustive. Although the table recapitulates studies on MSC death modulation function depending on tunneling nanotubes, this does not exclude the implication of other modes of actions. Studies are ordered from the oldest to the most recent. BM-MSCs, bone marrow mesenchymal stem/stromal cells; ASCs, adipose tissue mesenchymal stem/stromal cells; EVs, extracellular vesicles; TNTs, tunneling nanotubes; Cxs, connexins; LPS, lipopolysaccharide; HUVEC, human umbilical vein endothelial cells; LAD, left anterior descending