Skip to main content

Advertisement

Table 4 Mesenchymal stem/stromal cell (MSC) death modulation function depending on extracellular vesicles

From: Mesenchymal stem/stromal cell function in modulating cell death

Studies Sources of MSCs MSC death modulation function Modes of actions References
Preclinical in vitro Human BM-MSCs Apoptosis in human A549ρ0 lung epithelial cell line induced by ethidium bromide Transfer of mitochondria via EVs or TNTs or both Spees et al. [27]
Preclinical in vivo Mouse and human BM-MSCs Apoptosis in alveolar epithelial cells induced by LPS in vivo in an acute lung injury mouse model Cx-43, transfer of mitochondria via EVs and TNTs Islam et al. [43]
Preclinical in vitro and in vivo Human BM-MSCs Apoptosis in human MCF-7 breast cancer cell line and human KHOS osteosarcoma cell line induced by deprivation of serum. Apoptosis in vivo in MCF-7 inoculated in a NU/NU mouse model Transfer of miRNA-21 and miRNA-34a via EVs Vallabhaneni et al. [72]
Preclinical in vitro and in vivo Human BM-MSCs Apoptosis in human primary MSCs and in mouse RAW 264.7 macrophage cell line induced by oxidative stress and/or silica particles in vitro and in vivo in a mouse silicosis model Transfer of mitochondria and miRNA-451 via EVs Phinney et al. [73]
Preclinical in vivo Human UC-MSCs Apoptosis in human HFL1 lung fibroblast, HaCAT keratinocyte cell line, and rat primary dermal fibroblasts induced by heat stress in vitro. Apoptosis in rat skin epithelial cells in vivo in a rat burn model Transfer of Wnt4 via EVs Zhang et al. [93]
Preclinical in vitro and in vivo Mouse and human BM-MSCs Apoptosis in mouse primary bone marrow cells and mouse FDC-P1 hematopoietic cell line induced by γ-irradiation with xenotransplantation in a mouse model Transfer of miRNA-210-5p, miRNA-106b-3p, and miRNA-155-5p via EVs Wen et al. [51]
Clinical Human BM-MSCs Apoptosis and necrosis in alveolar epithelial cells in patients with ARDS Immunosuppressive and/or trophic factors and/or EVs Simonson et al. [63]
Preclinical in vitro and in vivo Human ASCs Apoptosis in human primary cardiomyocytes or endothelial cells induced by ethidium bromide, hydrogen peroxide, or doxorubicin. Apoptosis in mouse cardiomyocytes induced in a myocardial infarction mouse model with LAD artery ligation Transfer of mitochondria via EVs and/or TNTs, and Heme oxygenase Mahrouf-Yorgov et al. [46]
Preclinical in vitro Human BM-MSCs Apoptosis and necroptosis human primary B cell chronic lymphocytic leukemia induced by bortezomib, cladribine, fludarabine, flavopiridol, or methylprednisolone (others) EVs Crompot et al. [40]
Preclinical in vitro and in vivo Human UC-MSCs Apoptosis in Human L02 hepatocyte cell line induced by hydrogen peroxide or carbon tetrachloride. Apoptosis induced in mouse hepatocyte in vivo by carbon tetrachloride in NU/NU mouse model Transfer of GPX1 via EVs Yan et al. [92]
Preclinical in vitro and in vivo Human iPSC-MSCs Necroptosis in Human HK-2 epithelial cell line induced by deprivation of oxygen. Necroptosis in renal rat epithelial cells induced in vivo by clamping of renal pedicles in an acute kidney injury rat model Transfer of SP1 via EVs Yuan et al. [53]
Preclinical in vitro and in vivo Mouse BM-MSCs Apoptosis in mouse primary cardiomyocytes induced by deprivation of oxygen and serum. Apoptosis in mouse cardiomyocytes in vivo in a myocardial infarction mouse model induced by LAD artery ligation Transfer of miRNA-125b via EVs Xiao et al. [62]
Preclinical in vitro Human WJ-MSCS Apoptosis in mouse Neuro2a neuroblastoma cell line induced by deprivation of glucose and oxygen Transfer of miRNA let-7a, let-7e, and let-7-5p via EVs Joerger-Messerli et al. [71]
Preclinical in vitro and in vivo Human UC-MSCs Apoptosis in human H1299 and PC-9 lung adenocarcinoma cell lines induced by deprivation of serum. Apoptosis in vivo in human lung H1299 adenocarcinoma cell line in vivo after xenotransplantation in a NU/NU mouse model Transfer of miRNA-410a via EVs Dong et al. [70]
  1. This table is representative but not exhaustive. Although the table recapitulates studies on MSC death modulation function depending on extracellular vesicles, this does not exclude the implication of other modes of actions. Studies are ordered from the oldest to the most recent. BM-MSCs, bone marrow mesenchymal stem/stromal cells; ASCs, adipose tissue mesenchymal stem/stromal cells; iPSC-MSCs, inducible pluripotent stem/stromal cell mesenchymal stem cells; WJ-MSCs, Wharton’s jelly mesenchymal stem/stromal cells; UC-MSCs, umbilical cord mesenchymal stem/stromal cells; EVs, extracellular vesicles; TNTs, tunneling nanotubes; Cxs, connexins; LPS, lipopolysaccharide; miRNA, microRNA; LAD, left anterior descending; Wnt, wingless type; ARDS, acute respiratory distress syndrome; GPX, glutathione peroxidase; SP, specificity protein