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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway

Fig. 3

Continuous single-dose ISO altered the muscle fiber types. a MyHC1, as one of type I muscle fiber maker, were repressed in differentiated C2C12 cells continuously exposed to different doses of ISO by detecting the levels of mRNA using Real-time PCR. b-d Type II muscle fiber makers such as MyHC2a, MyHC2b and MyHC2x have shown the reduced changes of mRNA expressions in differentiated C2C12 cells following continuous single-dose ISO stimulation of mRNA expressions in differentiated C2C12 cells following continuous single-dose ISO stimulation. $P = 0.0000 vs. Ctrl; #P = 0.00368 vs. 10-8 M ISO; &P = 0.0826 vs. 10-7 M ISO; *P = 0.0004 vs. 10-6 M ISO; n = 6

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