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Table 2 Detailed information on outcomes extracted from the included studies

From: Efficacy of stem cell therapy for pulmonary arterial hypertension: a systematic review and meta-analysis of preclinical studies

Author (year)

Total N, M, SD of Animals (treatment/control)

Primary outcomes

Secondary outcomes

RVSP

mPAP

mRVP

RV/LV+S

RV/BW

WA

WT

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

N1, MD1, SD1; N2, MD2, SD2

Lim et al.(2016) [39]

5,34.95,1.57;5,39.79,1.57

  

5,0.47,0.03;5,0.52,0.01

   

Lee et al. (2017) [36]

  

6,16,1.63;4,29,3.63

6,0.31,0.02;4,0,36,0.0025

4,0.91,0.03;4,0.69,0.01

 

6,32.52,0.91;4,42.31,0.9

6,14,0.75;4,49.5,8

6,0.69,0.04;4,0.8,0.08

4,1.75,0.03;4,0.62,0.01

4,34.76,2.71;4,38.22,3.1

4,14,0.75;4,27,2

4,0.32,0.0025;4,0.4,0.01

4,0.85,0.02;4,0.69,0.01

4,36.16,0.93;4,40.9,2.08

4,13,1.75;4,44,1.75

4,0.62,0.02;4,0.81,0.06

4,1.52,0.04;4,0.62,0.01

 

Guo et al. (2013) [30]

10,94.69,9.03;10,95.55,12.53

10,29.99,6.08;10,30.26,7.83

 

10,0.34,0.06;10,0.37,0.08

   

Luan et al.(2012) [42]

20,43.83,2.13;20,56.84,1.54

20,26.82,2.13;20,41.37,2.24

20,28.34,1.98;20,41.7,6.17

 

20,0.547,0.04;20,0.613,0.07

 

20,20.83,5.49;20,45.21,4.37

Baber et al. (2006) [25]

 

10,33.48,6;10,44.3,6.35

 

10,0.47,0.03;10,0.6,0.02

   

Chen et al. (2014) [27]

  

7,13.51,1.25;7,29.9,0.71

7,0.34,0.03;7,0.56,0.02

 

7,78.62,2.58;7,95.17,10.35

7,49.18,3.46;7,73.77,2.77

Chen et al. (2016) [26]

10,28,1.57;10,43,3.18

  

10,0.55,0.08;10,0.78,0.41

  

10,21.21,0.02;10,29.16,0.04

Cheng et al. (2017) [29]

10,43.76,2.11;10,60.85,1.2

  

10,0.43,0.05;10,0.58,0.02

10, 0.42, 0.05;10, 0.51, 0.09

  

Huang et al.(2016) [31]

6,47.99,5.53;6,66.7,1.74

  

6, 0.48, 0.04;6, 0.68, 0.09

   

Chen et al.(2016) [28]

8, 29.01,1.67; 8,45.81,2.63

     

8,18.76,1.09; 8,30.44,2.23

Jiang et al.(2012) [32]

43, 28.84, 1.35; 18, 40.2, 3.46

  

43, 0.38, 0.05; 18, 0.58, 0.03

  

43, 36.24, 1.51; 18, 53.47, 3.52

Kang et al. (2015) [33]

10, 32.72, 1.19; 10, 42.24, 7.52

  

10, 0.5, 0.01; 10, 0.54, 0.07

  

10.32.4, 4; 10, 42, 7.4

Kimet al (2012) [34]

  

6, 15.4, 3.8; 6, 38.4, 7.4

6, 0.33, 0.06; 6, 0.53, 0.04

6, 0.73, 0.02; 6, 0.82, 0.05

 

6, 29.3, 5.2; 6, 38.8, 1.9

6, 14.8, 3.6; 6, 42.3, 13

6, 0.64, 0.06; 6, 0.79, 0.04

6, 1.47, 0.02; 6, 1.7, 0.09

6, 35.7, 5.7; 6, 40.2, 5.4

Kim et al. (2016) [35]

  

6, 16.4, 2.1; 6, 34.8, 7.3

6, 0.34, 0.27; 6, 0.38, 0.05

6, 0.75, 0.02; 6, 0.82, 0.05

 

6, 31.07, 4.71; 6, 38.84, 1.94

6, 13.4, 2.5; 6, 42.2, 13

6, 0.48, 0.1; 6, 0.79, 0.04

6, 1.3, 0.05; 6, 1.7, 0.07

6, 33.64, 3.57; 6, 40.19, 5.38

Liang et al. (2015) [38]

 

10, 16.37, 0.94; 10, 26.88, 0.86

     

10, 18.26, 1.41; 8, 32.22, 0.71

Liu et al. (2015) [40]

8, 29.86, 2.87; 8, 47.13, 3.31

     

8, 17.53, 1.24; 8, 31.78, 2.16

Luan et al. (2013) [43]

 

10, 31.57, 5.54; 10, 44.97, 4.26

 

10, 0.43, 0.05; 10, 0.59, 0.03

 

10, 45.69, 4.21; 10, 56.52, 4.5

10, 26.28, 3.95; 10, 36.56, 3.68

Luo et al. (2014) [44]

 

8, 18.63, 2.15; 8, 24.53, 2.9

 

8, 0.36, 0.04; 17, 0.43, 0.12

 

8, 58.23, 4.08; 8, 68.7, 3.43

8, 38.06, 4.15; 8, 46.09, 4.7

8, 23.07, 2.84; 8, 33.18, 3.28

8, 0.39, 0.04; 8, 0.49, 0.02

8, 62.97, 6.58; 8, 80.48, 6.19

8, 40.91, 5.24; 8, 57.26, 4.32

8, 22.98, 3.24; 8, 36.38, 3.28

8, 0.41, 0.01; 8, 0.51, 0.01

8, 65.27, 5.45; 8, 84.01, 2.76

8, 41.91, 5.16; 8, 64.64, 3.86

Raoul et al. (2007) [45]

5, 17.65, 2.16; 5, 27.77, 0.94

  

5, 0.3, 0.03; 5, 0.35, 0.02

   

Rathinasabapathy et al. (2016) [46]

       

Somanna et al. (2014) [47]

 

6, 52.6, 2.79; 6, 56.24, 3.1

6, 053, 0.04; 6, 0.51, 0.03

6, 0.53, 0.04; 6, 0.51, 0.03

   

Zhang et al. (2012) [49]

9, 32.85, 3.44; 9, 59.12, 4.32

  

9, 0.23, 0.01; 9, 0.31, 0.01

  

9, 29.97, 2.21; 9, 53.47, 3.52

Zhang et al. (2012) [50]

10, 43.83, 2.13; 10, 56.84, 1.54

10, 26.82, 3.42; 10, 41.37, 2.24

10, 28.34, 1.98; 10, 41.7, 6, 17

 

10, 0.547, 0.041; 10, 0.613, 0.072

  

Umar et al. (2009) [48]

10, 31, 4; 10, 42, 17

  

10, 0.32, 0.07; 10, 0.47, 0.12

10, 0.64, 0.01; 10, 0.93, 0.21

  

Liu et al. (2011) [41]

 

16, 19.83, 2.32; 17, 33.33, 5.36

 

16, 0.36, 0.04; 17, 0.43, 0.12

   

Takemiya et al. (2009) [15]

10, 43.73, 3.37; 10, 65.56, 2.3

      

Horimoto et al. (2005) [14]

10, 42.3, 1.1; 10, 58.7, 1.86

   

10, 0.462, 0.029; 10, 0.59, 0.084

  

Lee et al. (2015) [37]

  

8, 23.6, 7.6; 8, 36.5, 3.1

8, 1.43, 0.14; 8, 1.47, 0.18

8, 1.14, 0.21; 8, 1.01, 0.1

 

8, 34.2, 4; 8, 38.5; 4

8, 21.3, 4.9; 8, 37.2, 6.3

8, 2.18, 0.45; 8, 2.89, 0.43

8, 1.72, 0.33; 8, 1.62, 0.24

8, 33.2, 3.9; 8, 38.8, 6.3

8, 16.5, 3.6; 8, 52, 19.7

8, 1.85, 0.28; 8, 2.88, 0.58

8, 1.81, 0.15; 8, 2.67, 0.04

8, 37.3, 1.5; 8, 32.3; 2.5

  1. N sample number, M mean, SD standard deviation, RVSP right ventricular systolic pressure, mPAP mean pulmonary arterial pressure, mRVP mean right ventricle pressure, RV/LV+S the weight ratio of the right ventricle to the left ventricle plus septum, RV/BW right ventricle to body weight ratio, WA pulmonary arteriole area index, WT wall thickness of pulmonary arteriole