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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Priming with Toll-like receptor 3 agonist or interferon-gamma enhances the therapeutic effects of human mesenchymal stem cells in a murine model of atopic dermatitis

Fig. 2

Priming with pro-inflammatory molecules affects the gene expression profiles of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). a Schematics of the priming of WJ-MSCs with poly I:C or interferon-gamma (IFN-γ). b Heat maps of upregulated (red) and downregulated (green) genes in poly I:C- and IFN-γ-primed WJ-MSCs compared with non-primed WJ-MSCs (control). c Venn diagram of mRNAs commonly or differentially expressed in poly I:C- and IFN-γ-primed WJ-MSCs. d Top 10 canonical pathways commonly enriched in poly I:C- and IFN-γ-primed WJ-MSCs. e A heat map of the top 20 diseases and bio-functions enriched in poly I:C- or IFN-γ-primed WJ-MSCs. Diseases and bio-functions are sorted by the activation z-score

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