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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects

Fig. 4

Radiographic and micro-CT observation and analysis of miRNA-21-induced bone regeneration in canine mandible defects. a Radiographic observations of β-TCP, Lenti-LacZ/β-TCP/BMSC, and Lenti-miRNA-21/β-TCP/BMSC scaffolds 2 weeks, 3 months, and 6 months postoperation. A sham operation group served as the control. b Cross-section micro-CT images of canine mandibles with scaffolds 6 months postoperation. c Quantitative results from micro-CT evaluations of the four groups (three animals in each group). The experiment was repeated three times. The green dotted pane denotes micro-CT images of the middle sections of canine mandibular defects. The red dotted pane indicates 3D reconstruction of canine mandibular defects (*p < 0.05; #p < 0.05)

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