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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects

Fig. 5

Histological analysis and fluorochrome labeling of miRNA-21-induced bone regeneration in canine mandibular defects. a Histological observations of undecalcified sections stained with van Gieson’s picrofuchsin from the four groups. b Histomorphometric measurements of the four groups (three animals in each group). The experiment was repeated three times. c Sequential fluorescence labeling of β-TCP, Lenti-LacZ/β-TCP/BMSC, and Lenti-miRNA-21/β-TCP/BMSC scaffolds. d Quantitative analysis of β-TCP, Lenti-LacZ/β-TCP/BMSC, and Lenti-miRNA-21/β-TCP/BMSC scaffolds. Yellow, green, and red represent labeling by tetracycline hydrochloride (TE), calcein (CA), and Alizarin Red (ARS), respectively (three animals in each group). The experiment was repeated three times. The bone area stained with TE, CA, and ARS was calculated (*p < 0.05; #p < 0.05)

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