Fig. 1

The effect of mMSCs overexpressing p130 or E2F4 on the histopathology of LPS-induced lung injury in mice. a–f Representative histopathological images of the lung tissues from mice of all the experimental groups at 7 and 14 days after LPS challenge (HE staining, × 200). Alveolar wall thickening was marked as red triangle. Inflammatory cell infiltration was marked as yellow arrow, and haemorrhage was marked as green arrow. g Lung injury score (Smith score) of the lung tissues from mice of all the experimental groups at 7 and 14 days after LPS challenge (n = 3 at each time-point for each group; *p < 0.05 compared with the control group; #p < 0.05 compared with the ARDS group; δp < 0.05 compared with the LPS+MSC-NC group). ARDS acute respiratory distress syndrome, mMSCs mouse mesenchymal stem cells, NC normal control