Fig. 5

The effect of mMSCs overexpressing p130 or E2F4 on the permeability of LPS-induced lungs in mice. a Lung oedema was analysed by LWW/BW. The results are shown for samples of all the experimental groups at 7 and 14 days after LPS exposure (n = 3, *p < 0.05 compared with the control group; #p < 0.05 compared with the ARDS group; δp < 0.05 compared with the LPS+MSC-NC group). b Total protein and c albumin concentrations in bronchoalveolar lavage fluid were analysed by a mouse-specific ELISA kit to evaluate the epithelial permeability of the lung (n = 3, *p < 0.05 compared with the control group; #p < 0.05 compared with the ARDS group; δp < 0.05 compared with the LPS+MSC-NC group). d Expression of the occludin protein in the lungs of all the experimental groups at 7 and 14 days after mMSC administration was evaluated by western blot analysis (n = 3, *p < 0.05 compared with the control group; #p < 0.05 compared with the ARDS group; δp < 0.05 compared with the LPS+MSC-NC group). e Alveolar fluid clearance was measured at 7 and 14 days after mMSC administration (n = 3, *p < 0.05 compared with the control group; #p < 0.05 compared with the ARDS group; δp < 0.05 compared with the LPS+MSC-NC group). ALB albumin, ARDS acute respiratory distress syndrome, ELISA enzyme-linked immunosorbent assay, LWW/BW lung wet weight/body weight, mMSCs mouse mesenchymal stem cells, NC normal control, TP total protein