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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats

Fig. 6

Stages of osteochondral defect creation and the surgical procedure of repairing osteochondral defect with BMSCs/pTa-chondrocytes/CM. a The chondrocytes were isolated from articular cartilage from the knees of 10-month-old goats. b BMSCs were isolated from the marrow of femoral condyle of 10-month-old goats. c Osteochondral defect model with 10.0-mm diameter and 12.0-mm depth in femoral heads was established. d The 10.0-mm-diameter and 10.0-mm-depth pTa cylinder with autologous BMSCs were implanted in subchondral bone defect sites. e Preparation of fibrin sealant. f The 10.0-mm-diameter CM with autologous chondrocytes was adhered to tantalum rods by fibrin sealant. g Suture of joint capsule. h X-ray showed the position of pTa at 16 weeks post-implantation

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