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Scheme 1 | Stem Cell Research & Therapy

Scheme 1

From: Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats

Scheme 1

Schematic for the repairing of large osteochondral defects in goats’ femoral head with BMSCs/pTa-chondrocytes/CM biphasic scaffold. Chondrocytes and BMSCs were harvested from goat femora and femoral condyle, respectively (A). Chondrocytes (B1) and BMSCs (B2) were proliferated in vitro (C1, C2). Cartilaginous and osseous component scaffold were seeded with chondrocytes and BMSCs, respectively (D1, D2) and co-culture (E1, E2). mRNA expression of chondrogenic genes (F1) and osteogenic genes (F2). The cartilaginous and osseous component were combined with the fibrin sealant to form osteochondral construct (G), which was implanted into the femoral head of the homologous goat for 16 weeks (H)

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Stem Cell Research & Therapy

ISSN: 1757-6512