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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats

Fig. 4

Exosome uptake and acceleration of the activation of SCs. A Pax7+ cells were stained green, while MyoD+ cells were stained red. Nuclei were stained blue. After cultivation with USCs-Exo, the number of activated SCs (Pax7+/MyoD+) increased significantly. B Exosome uptake. Exosomes were stained green and shown as bright green dots (arrowheads), while the nuclei were stained blue. C Statistical result of SC activation. The cells were activated after cultivation with USCs-Exo, and the number of activated cells reached a maximum at 24 h. D RT-PCR results of Pax3 and Pax7 mRNAs. The expression of Pax3 and Pax7 in SCs increased after cultivation with USCs-Exo. E RT-PCR results of cyclin mRNAs. The expression of cyclin B, cyclin D1, and cyclin E increased after cultivation with USCs-Exo (Exo, USCs-Exo; ctl, control; *P < 0.05, ***P < 0.001; n.s., no significance; × 100 magnification)

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