Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys

Fig. 1

Peripheral delivery of hUC-MSCs ameliorates liver injury and rescues monkeys from lethal ALF. a Schematic representation of the experimental design. b Survival curves for the monkeys submitted to different treatments (Kaplan–Meier method with log-rank test). c Biochemical assays of hepatic indexes: alanine aminotransferase (ALT), glutamic-oxaloacetic transaminase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), prothrombin time (PT), activated partial thromboplastin time (APTT), lactate dehydrogenase (LDH), blood ammonia (BA), uric acid (UA), and albumin (ALB). Error bars, SEM. Mann–Whitney U test, *P < 0.05, &P < 0.01, and $P < 0.001. d HE staining, Oil red O staining, and Ki67 immunohistochemical staining of liver specimens at indicated days. e Quantitation of Ki67+ positive hepatocytes at indicated time points following different treatments. The numbers of positive cells in 10 consecutive high-power fields were counted. Student’s t test, each bar represents the mean ± s.e.m. of positive cells in liver sections from at least three monkeys. f Histology of biopsied liver specimens obtained from hUC-MSC-treated monkeys after 2 months of follow-up

Back to article page