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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys

Fig. 4

Delayed hUC-MSC treatment improves outcomes in monkeys challenged with toxins. a Schematic representation of the experimental design. b Survival curves for the monkeys submitted to different treatments (Kaplan–Meier method with log-rank test). c Biochemical assays of hepatic indexes: alanine aminotransferase (ALT), glutamic-oxaloacetic transaminase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), prothrombin time (PT), activated partial thromboplastin time (APTT), blood ammonia (BA), and uric acid (UA). Error bars, SEM. Mann–Whitney U test, *P < 0.05. d Serum levels of cytokines, chemokines, and growth factors. IL, interleukin; TNF-α, tumor necrosis factor; MCP-1, monocyte chemoattractant protein-1; INF-γ, interferon γ; MIP-1α, macrophage inflammatory protein-1α; MIP-1α, macrophage inflammatory protein-1β. N = 5–7; error bars, SEM. Mann–Whitney U test, *P < 0.05

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