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Table 1 Current methods for generating induced pluripotent stem cells

From: The potential and limitations of induced pluripotent stem cells to achieve wound healing

  MMLV-derived retrovirus Lentivirus piggyBac Adenovirus Sendai virus Plasmid Episome Minicircle RNA delivery Protein delivery
Non-integrative + + + + + + +
DNA-free + +
Efficient ++ ++ + + + + + ++
Safe + + + + + + ++ ++
  1. Current methods of induced pluripotent stem cell derivation, their advantages, and limitations. Non-integrative: + yes, − no. DNA free: + yes, − no. Efficient: ++ high, + medium, − low. Safe: ++ high, + medium, − low