The potential and limitations of induced pluripotent stem cells to achieve wound healing

Table 1 Current methods for generating induced pluripotent stem cells

	MMLV-derived retrovirus	Lentivirus	piggyBac	Adenovirus	Sendai virus	Plasmid	Episome	Minicircle	RNA delivery	Protein delivery
Non-integrative	−	−	−	+	+	+	+	+	+	+
DNA-free	−	−	−	−	−	−	−	−	+	+
Efficient	++	++	+	−	+	+	+	+	++	–
Safe	–	–	+	+	+	+	+	+	++	++

Current methods of induced pluripotent stem cell derivation, their advantages, and limitations. Non-integrative: + yes, − no. DNA free: + yes, − no. Efficient: ++ high, + medium, − low. Safe: ++ high, + medium, − low

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