Table 2 Major skeletal muscle-resident cell populations
From: The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function
| Muscle-resident cell population | Species | Surface marker in majority of cells | Surface marker in subset of cells | In vitro lineage potential | In vivo lineage potential | Reference |
|---|---|---|---|---|---|---|
| Satellite cell | Mouse | Vcam-1 (CD106), Synd3/4, M-Cadherin, SM/C-2.6, Caveolin-1, Calcitonin receptor, β1-integrin, CXCR4, α7-integrin, CD34 | c-Met, Jagged-1, CD56 | Myogenic, adipogenic and osteogenic | Myogenic | [27, 40, 148,149,150,151,152,153,154] |
| Human | CD56 (NCAM), M-cadherin, α7-integrin, CD82, CD318 | CD146 (MCAM) | Myogenic, osteogenic | Myogenic | [98, 155,156,157,158] | |
| FAP | Mouse | PDGFRα, Sca-1, CD34 | Tie2 | Fibrogenic, adipogenic and osteogenic | Fibrogenic, adipogenic and osteogenic | [26, 27, 77, 85] |
| Human | PDGFRα, CD15, CD201 | CD166 | Fibrogenic, adipogenic and osteogenic | Fibrogenic, adipogenic and osteogenic | [96,97,98, 159] | |
| Endothelial and myo-endothelial cell | Mouse | CD31, Sca-1, Tie2 (90%), VE-cadherin (90%) | β4-integrin (10%) | Myogenic and adipogenic | Myogenic | [79] |
| Myogenic-endothelial progenitor | Mouse | CD34, Sca-1 | Myogenic, endothelial and adipogenic | Myogenic and endothelial cell | [104] | |
| Human | CD34, CD56, CD144 (VE-cadherin) | Myogenic, adipogenic, osteogenic, chondrogenic and endothelial cell | Myogenic, osteogenic, chondrogenic and endothelial cell | [28, 105] | ||
| Pericyte | Mouse | PDGFRβ, CD146, NG2 | Sca-1, CD34, PDGFRα, Nestin | Myogenic adipogenic | Myogenic, adipogenic and pericyte | [108, 110, 111] |
| Human | PDGFRβ, CD146, NG2 | Myogenic, adipogenic, osteogenic and chondrogenic | Myogenic osteogenic | [109, 112] | ||
| PIC | Mouse | Sca-1, CD34 | PDGFRα, PDGFRβ | Myogenic, smooth muscle cell and adipogenic | Myogenic | [129, 130, 134] |
| Twist2+ progenitor | Mouse | β1-integrin, Sca-1, PDGFRα, PDGFRβ | Myogenic and osteogenic | Myogenic | [132] | |
| Interstitial myogenic cell | Mouse | β4-integrin (CD104), β1-integrin (60%), Sca-1 (55%) | CD31, CD34, α7-integrin (34%) | Myogenic | Myogenic | [160] |