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Table 2 Major skeletal muscle-resident cell populations

From: The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function

Muscle-resident cell population Species Surface marker in majority of cells Surface marker in subset of cells In vitro lineage potential In vivo lineage potential Reference
Satellite cell Mouse Vcam-1 (CD106), Synd3/4, M-Cadherin, SM/C-2.6, Caveolin-1, Calcitonin receptor, β1-integrin, CXCR4, α7-integrin, CD34 c-Met, Jagged-1, CD56 Myogenic, adipogenic and osteogenic Myogenic [27, 40, 148,149,150,151,152,153,154]
Human CD56 (NCAM), M-cadherin, α7-integrin, CD82, CD318 CD146 (MCAM) Myogenic, osteogenic Myogenic [98, 155,156,157,158]
FAP Mouse PDGFRα, Sca-1, CD34 Tie2 Fibrogenic, adipogenic and osteogenic Fibrogenic, adipogenic and osteogenic [26, 27, 77, 85]
Human PDGFRα, CD15, CD201 CD166 Fibrogenic, adipogenic and osteogenic Fibrogenic, adipogenic and osteogenic [96,97,98, 159]
Endothelial and myo-endothelial cell Mouse CD31, Sca-1, Tie2 (90%), VE-cadherin (90%) β4-integrin (10%) Myogenic and adipogenic Myogenic [79]
Myogenic-endothelial progenitor Mouse CD34, Sca-1   Myogenic, endothelial and adipogenic Myogenic and endothelial cell [104]
Human CD34, CD56, CD144 (VE-cadherin)   Myogenic, adipogenic, osteogenic, chondrogenic and endothelial cell Myogenic, osteogenic, chondrogenic and endothelial cell [28, 105]
Pericyte Mouse PDGFRβ, CD146, NG2 Sca-1, CD34, PDGFRα, Nestin Myogenic adipogenic Myogenic, adipogenic and pericyte [108, 110, 111]
Human PDGFRβ, CD146, NG2   Myogenic, adipogenic, osteogenic and chondrogenic Myogenic osteogenic [109, 112]
PIC Mouse Sca-1, CD34 PDGFRα, PDGFRβ Myogenic, smooth muscle cell and adipogenic Myogenic [129, 130, 134]
Twist2+ progenitor Mouse β1-integrin, Sca-1, PDGFRα, PDGFRβ   Myogenic and osteogenic Myogenic [132]
Interstitial myogenic cell Mouse β4-integrin (CD104), β1-integrin (60%), Sca-1 (55%) CD31, CD34, α7-integrin (34%) Myogenic Myogenic [160]
  1. VCAM-1 vascular cell adhesion molecule-1, MCAM melanoma cell adhesion molecule, NCAM neural cell adhesion molecule, FAP fibroadipogenic progenitor, PIC PW1-expressing interstitial cell, NG2 neuron-glial antigen