Table 2 Major skeletal muscle-resident cell populations
From: The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function
Muscle-resident cell population | Species | Surface marker in majority of cells | Surface marker in subset of cells | In vitro lineage potential | In vivo lineage potential | Reference |
|---|---|---|---|---|---|---|
Satellite cell | Mouse | Vcam-1 (CD106), Synd3/4, M-Cadherin, SM/C-2.6, Caveolin-1, Calcitonin receptor, β1-integrin, CXCR4, α7-integrin, CD34 | c-Met, Jagged-1, CD56 | Myogenic, adipogenic and osteogenic | Myogenic | |
Human | CD56 (NCAM), M-cadherin, α7-integrin, CD82, CD318 | CD146 (MCAM) | Myogenic, osteogenic | Myogenic | ||
FAP | Mouse | PDGFRα, Sca-1, CD34 | Tie2 | Fibrogenic, adipogenic and osteogenic | Fibrogenic, adipogenic and osteogenic | |
Human | PDGFRα, CD15, CD201 | CD166 | Fibrogenic, adipogenic and osteogenic | Fibrogenic, adipogenic and osteogenic | ||
Endothelial and myo-endothelial cell | Mouse | CD31, Sca-1, Tie2 (90%), VE-cadherin (90%) | β4-integrin (10%) | Myogenic and adipogenic | Myogenic | [79] |
Myogenic-endothelial progenitor | Mouse | CD34, Sca-1 | Â | Myogenic, endothelial and adipogenic | Myogenic and endothelial cell | [104] |
Human | CD34, CD56, CD144 (VE-cadherin) | Â | Myogenic, adipogenic, osteogenic, chondrogenic and endothelial cell | Myogenic, osteogenic, chondrogenic and endothelial cell | ||
Pericyte | Mouse | PDGFRβ, CD146, NG2 | Sca-1, CD34, PDGFRα, Nestin | Myogenic adipogenic | Myogenic, adipogenic and pericyte | |
Human | PDGFRβ, CD146, NG2 |  | Myogenic, adipogenic, osteogenic and chondrogenic | Myogenic osteogenic | ||
PIC | Mouse | Sca-1, CD34 | PDGFRα, PDGFRβ | Myogenic, smooth muscle cell and adipogenic | Myogenic | |
Twist2+ progenitor | Mouse | β1-integrin, Sca-1, PDGFRα, PDGFRβ |  | Myogenic and osteogenic | Myogenic | [132] |
Interstitial myogenic cell | Mouse | β4-integrin (CD104), β1-integrin (60%), Sca-1 (55%) | CD31, CD34, α7-integrin (34%) | Myogenic | Myogenic | [160] |