Fig. 4

The inflammation, differentiation, and chondrogenesis. a, b The expression level of stemness and differentiation markers in BMSCs (a) and inflammatory factors in SnChos (b) in co-culture at 7 and 21 days (n = 3). The MSCs (7 days) or SnChos (7 days) were used as control. c, d The generation of cartilage matrix protein Col II and Agg by BMSCs (c) and SnChos (d) in co-culture at 21 days (n = 3). The protein levels were normalized to GAPDH. *P < 0.05, **P < 0.01