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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma

Fig. 7

The hAMSC-SBE4-TRAIL delivery system has a potential clinical applications for GBM therapy. Our work sought to hAMSCs which augment the expression of TRAIL under the trigger of TGF-β-secreting primary GBMs and avoid unspecific TRAIL secretion into non-target cells. The results on the controlled release of the suicide gene delivery system demonstrate a significant improvement for the clinical utility of biological strategy to treat brain cancers, especially for the patients in whom tumor mass express elevated level of TGF-β

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Stem Cell Research & Therapy

ISSN: 1757-6512