Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: HMGB1-modified mesenchymal stem cells attenuate radiation-induced vascular injury possibly via their high motility and facilitation of endothelial differentiation

Fig. 6

Illustration of possible mechanisms that HMGB1 modification improves the efficacy of mesenchymal stem cells (MSCs) in treating the radiation-induced vascular injury. HMGB1-modified MSCs (MSC-H cells) produce and actively release HMGB1 to the extracellular milieu. Extracellular HMGB1 binds to and signals via its receptors on MSC-H cells which are activated to generate more HMGB1 via a positive feedback loop. Besides, extracellular HMGB1 primes MSCs to increase their mobility and differentiation toward endothelial lineage. Multiple pathways are involved in the process, including the SDF-1/CXCR4 axis, MAPK, and p53 signaling. Thus, the ability of MSCs to regenerate is improved and later translated to their high efficacy in inhibiting neointima formation after irradiation

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512