TY - JOUR AU - Thomi, Gierin AU - Surbek, Daniel AU - Haesler, Valérie AU - Joerger-Messerli, Marianne AU - Schoeberlein, Andreina PY - 2019 DA - 2019/03/21 TI - Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury JO - Stem Cell Research & Therapy SP - 105 VL - 10 IS - 1 AB - Preterm newborns are at high risk of developing neurodevelopmental deficits caused by neuroinflammation leading to perinatal brain injury. Human Wharton’s jelly mesenchymal stem cells (hWJ-MSC) derived from the umbilical cord have been suggested to reduce neuroinflammation, in part through the release of extracellular vesicle-like exosomes. Here, we studied whether exosomes derived from hWJ-MSC have anti-inflammatory effects on microglia-mediated neuroinflammation in perinatal brain injury. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-019-1207-z DO - 10.1186/s13287-019-1207-z ID - Thomi2019 ER -