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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

Fig. 1

Rat model of perinatal brain injury. a Schematic representation of the experimental outline. Perinatal brain injury was induced in postnatal day 2 (P2) rat pups by i.p. injection of LPS, followed by left common carotid artery cauterization 2 h later and exposure to hypoxia for 65 min. Hyaluronidase was administered into both nostrils 30 min before i.n. exosome or PBS application and the latter was done immediately before the cauterization of the left common carotid. b Detailed overview of the three experimental groups. ELISA enzyme-linked immunosorbent assay, Exo exosomes, i.p. intraperitoneal, i.n. intranasal, n number of animals, P2 postnatal day 2, RT-PCR reverse transcription polymerase chain reaction

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