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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

Fig. 4

Distinct and overlapping gene expression patterns between iMSCs and primary MSCs isolated from donors of distinct ages. a Venn diagram-based on expressed genes detected by microarrays of one sample each of fMSC-iMSCs, aMSC-iMSCs, and ESC-iMSCs. MSC-related genes were expressed in all three iMSC preparations. b Clustering dendrogram of Illumina gene expression experiments based on Pearson correlation. One cluster consists of iPSCs and ESCs (red box), and the other separated cluster contains primary MSCs as well as all three iMSC preparations (blue box). c Venn diagram of iMSCs and MSCs from fetal and aged donors based on expressed genes of one sample each d Heatmap showing clustering of primary MSCs and iMSCs for genes related to DNA damage repair. e Heatmap showing clustering of primary MSCs and iMSCs for aging-related genes

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