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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

Fig. 5

Identification of rejuvenation and aging signature. a Heatmap of genes expressed in MSCs but not in MSC-iMSCs and iPSCs (the aging signature) and of genes expressed in MSC-iMSCs and iPSCs but not in MSCs (the rejuvenation signature). b List of genes of the rejuvenation and aging signature. c Heatmap of genes in the rejuvenation and aging signature including published datasets [24, 25]. d Real-time PCR confirmation of a subset from rejuvenation and aging signature genes employing external MSC and additional iMSCs samples. Relative mRNA expression is shown normalized to expression in fMSCs

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