Fig. 6
From: Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Protein association network related to aging and rejuvenation signatures of gene expression in iMSCs and parental MSCs. Based on the Biogrid database protein interaction, networks have been constructed from the rejuvenation signature (a) and aging signature (b) listed in Fig. 5b. Most of the proteins coded by genes from both signatures can be connected to a network with interactions reported in the Biogrid database. Community clustering of the network via edge-betweenness reveals several communities with densely connected nodes and fewer connections across communities. Communities are indicated by dedicated color shading; edges between communities are colored red. a The rejuvenation signature PAN includes communities characterized by INHBE (blue), TP53, CDKN1C, IL32 (light blue), CDK10 (petrol), ELAVL1 (purple), DNMT3B (yellow), and EEF1A2 (green). b The aging signature PAN includes communities characterized by HSPA5 (blue), CCDC8 (purple), CAT (petrol), EYA2 (yellow), APP (green), and TGFB1 (red)