From: Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Stem cells types | Delivery mode | Wound types | Correction efficiency | Model source use | Treatment effect notes | Reference |
---|---|---|---|---|---|---|
BM-SCs | Scratch wound assay | Wound closure | 3 days | Human | Stimulate fibroblasts, migration of keratinocyte and synthesis ECM proteins | [238] |
BM-SCs | Tail vein injection post-operatively | Ischemia flap | 7 days | Murine | Enhance angiogenesis and vascular regeneration | [141] |
autologous MSC | Fibrin spray system | Cutaneous wound | 12 weeks | Murine and human | Stimulate closure of full-thickness wounds in diabetic mice and wound healing repair | [239] |
Combination hMSC with bFGF |  | Cutaneous wound | 42 days | Rat | Increase re-epithelialization | [240] |
Co-culture dermal fibroblasts with BM-SCs | Scratch wound assay | Wound closure | 3 days | Murine | Increase proliferation and migration of dermal fibroblasts | [241] |
MSCs | Subjection | Incision wound | 4 days | Mice | Enhance tissue regeneration capacity especially in older populations | [242] |
Autologous bone marrow | Aspiration | Chronic Wound | 5 weeks | Human | Rebuilding of dermal | [138] |
MSCs | Closed culture devices | Radiation burns | 5 months | Human | Modulation radiation inflammatory process | [243] |
Autologous MSCs | Injection | Diabetic ulcer | 4 weeks | Human | Successful healing | [244] |
Allogeneic BM-SCs | Intradermal | Excisional wound | 14 days | Murine | Accelerate wound closure, increase re-epithelialization and angiogenesis | [245] |
BM-SCs | Aspiration | Non-healing wound | 5 days | Human | Increase synthesis of collagen | [246] |
MSCs | Injection | Cutaneous wound | 2 weeks | Human | Promote angiogenesis | [247] |
MSCs | Mechanical loading | Incision wound | Â | Mouse | Enhancement of angiogenesis | [248] |
hUC-MSCs) | Transplantation | Burn | 8 weeks | Rat | Decrease inflammatory cells, increase neovascularization and enhance collagen level | [249] |
ASCs | Transplantation | Non-irradiated and irradiated | 14 days | Mouse | Promote dermal wound healing, enhance wound closure and collagen secretion | [250] |
hESCs | Grafting | Burn | Enhanced wound healing | Human-mice | hESC-derived epidermis showed a pluristratified structure, consistent with that of mature native human skin | [251] |
ESCs | Directly on a gauze | Chronic Wounds | Accelerated wound healing | Diabetic mice | The beneficial effects were evident both histopathologically and immunohistochemically | [252] |
Mouse-iPSCs | Grafting | Inherited skin disorders | Enhanced wound healing | Mouse | iPSC-KC stem cells were able to regenerate the epidermis, hair follicles, and sebaceous glands in an in vivo graft assay | [253] |
hiPSC-MSCs-Exos | Injected locally | Injured tissues | Facilitated cutaneous wound healing | Human-rat | Accelerated re-epithelialization, reduced scar widths, the promotion of collagen maturity, promoted the generation of newly formed vessels, accelerated their maturation in wound sites | [254] |
hiPSC | Grafting | Skin disease | Reconstitution of normal skin structures | Human-SCID mice | Skin appendages, such as hair follicles and glands, were not detected, and no cyst or tumor formation | [255] |
hiPSCs | Grafting | Inherited skin disorder | Reconstitute human skin | EB patient-SCID mice | The reconstituted skin expressed human Col17 at the basement membrane zone, human type VII collagen and human keratin 14 were expressed in the basal layer | [256] |