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Table 1 Stem cells used for in wound therapeutic

From: Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Stem cells types Delivery mode Wound types Correction efficiency Model source use Treatment effect notes Reference
BM-SCs Scratch wound assay Wound closure 3 days Human Stimulate fibroblasts, migration of keratinocyte and synthesis ECM proteins [238]
BM-SCs Tail vein injection post-operatively Ischemia flap 7 days Murine Enhance angiogenesis and vascular regeneration [141]
autologous MSC Fibrin spray system Cutaneous wound 12 weeks Murine and human Stimulate closure of full-thickness wounds in diabetic mice and wound healing repair [239]
Combination hMSC with bFGF   Cutaneous wound 42 days Rat Increase re-epithelialization [240]
Co-culture dermal fibroblasts with BM-SCs Scratch wound assay Wound closure 3 days Murine Increase proliferation and migration of dermal fibroblasts [241]
MSCs Subjection Incision wound 4 days Mice Enhance tissue regeneration capacity especially in older populations [242]
Autologous bone marrow Aspiration Chronic Wound 5 weeks Human Rebuilding of dermal [138]
MSCs Closed culture devices Radiation burns 5 months Human Modulation radiation inflammatory process [243]
Autologous MSCs Injection Diabetic ulcer 4 weeks Human Successful healing [244]
Allogeneic BM-SCs Intradermal Excisional wound 14 days Murine Accelerate wound closure, increase re-epithelialization and angiogenesis [245]
BM-SCs Aspiration Non-healing wound 5 days Human Increase synthesis of collagen [246]
MSCs Injection Cutaneous wound 2 weeks Human Promote angiogenesis [247]
MSCs Mechanical loading Incision wound   Mouse Enhancement of angiogenesis [248]
hUC-MSCs) Transplantation Burn 8 weeks Rat Decrease inflammatory cells, increase neovascularization and enhance collagen level [249]
ASCs Transplantation Non-irradiated and irradiated 14 days Mouse Promote dermal wound healing, enhance wound closure and collagen secretion [250]
hESCs Grafting Burn Enhanced wound healing Human-mice hESC-derived epidermis showed a pluristratified structure, consistent with that of mature native human skin [251]
ESCs Directly on a gauze Chronic Wounds Accelerated wound healing Diabetic mice The beneficial effects were evident both histopathologically and immunohistochemically [252]
Mouse-iPSCs Grafting Inherited skin disorders Enhanced wound healing Mouse iPSC-KC stem cells were able to regenerate the epidermis, hair follicles, and sebaceous glands in an in vivo graft assay [253]
hiPSC-MSCs-Exos Injected locally Injured tissues Facilitated cutaneous wound healing Human-rat Accelerated re-epithelialization, reduced scar widths, the promotion of collagen maturity, promoted the generation of newly formed vessels, accelerated their maturation in wound sites [254]
hiPSC Grafting Skin disease Reconstitution of normal skin structures Human-SCID mice Skin appendages, such as hair follicles and glands, were not detected, and no cyst or tumor formation [255]
hiPSCs Grafting Inherited skin disorder Reconstitute human skin EB patient-SCID mice The reconstituted skin expressed human Col17 at the basement membrane zone, human type VII collagen and human keratin 14 were expressed in the basal layer [256]