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Table 1 Stem cells used for in wound therapeutic

From: Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Stem cells types

Delivery mode

Wound types

Correction efficiency

Model source use

Treatment effect notes

Reference

BM-SCs

Scratch wound assay

Wound closure

3 days

Human

Stimulate fibroblasts, migration of keratinocyte and synthesis ECM proteins

[238]

BM-SCs

Tail vein injection post-operatively

Ischemia flap

7 days

Murine

Enhance angiogenesis and vascular regeneration

[141]

autologous MSC

Fibrin spray system

Cutaneous wound

12 weeks

Murine and human

Stimulate closure of full-thickness wounds in diabetic mice and wound healing repair

[239]

Combination hMSC with bFGF

 

Cutaneous wound

42 days

Rat

Increase re-epithelialization

[240]

Co-culture dermal fibroblasts with BM-SCs

Scratch wound assay

Wound closure

3 days

Murine

Increase proliferation and migration of dermal fibroblasts

[241]

MSCs

Subjection

Incision wound

4 days

Mice

Enhance tissue regeneration capacity especially in older populations

[242]

Autologous bone marrow

Aspiration

Chronic Wound

5 weeks

Human

Rebuilding of dermal

[138]

MSCs

Closed culture devices

Radiation burns

5 months

Human

Modulation radiation inflammatory process

[243]

Autologous MSCs

Injection

Diabetic ulcer

4 weeks

Human

Successful healing

[244]

Allogeneic BM-SCs

Intradermal

Excisional wound

14 days

Murine

Accelerate wound closure, increase re-epithelialization and angiogenesis

[245]

BM-SCs

Aspiration

Non-healing wound

5 days

Human

Increase synthesis of collagen

[246]

MSCs

Injection

Cutaneous wound

2 weeks

Human

Promote angiogenesis

[247]

MSCs

Mechanical loading

Incision wound

 

Mouse

Enhancement of angiogenesis

[248]

hUC-MSCs)

Transplantation

Burn

8 weeks

Rat

Decrease inflammatory cells, increase neovascularization and enhance collagen level

[249]

ASCs

Transplantation

Non-irradiated and irradiated

14 days

Mouse

Promote dermal wound healing, enhance wound closure and collagen secretion

[250]

hESCs

Grafting

Burn

Enhanced wound healing

Human-mice

hESC-derived epidermis showed a pluristratified structure, consistent with that of mature native human skin

[251]

ESCs

Directly on a gauze

Chronic Wounds

Accelerated wound healing

Diabetic mice

The beneficial effects were evident both histopathologically and immunohistochemically

[252]

Mouse-iPSCs

Grafting

Inherited skin disorders

Enhanced wound healing

Mouse

iPSC-KC stem cells were able to regenerate the epidermis, hair follicles, and sebaceous glands in an in vivo graft assay

[253]

hiPSC-MSCs-Exos

Injected locally

Injured tissues

Facilitated cutaneous wound healing

Human-rat

Accelerated re-epithelialization, reduced scar widths, the promotion of collagen maturity, promoted the generation of newly formed vessels, accelerated their maturation in wound sites

[254]

hiPSC

Grafting

Skin disease

Reconstitution of normal skin structures

Human-SCID mice

Skin appendages, such as hair follicles and glands, were not detected, and no cyst or tumor formation

[255]

hiPSCs

Grafting

Inherited skin disorder

Reconstitute human skin

EB patient-SCID mice

The reconstituted skin expressed human Col17 at the basement membrane zone, human type VII collagen and human keratin 14 were expressed in the basal layer

[256]