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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction

Fig. 5

Neutralization of TIPM-1, TIMP-2, and CXCL12 attenuated Nestin+ BMSC-mediated restoration of cardiac function after MI. a qRT-PCR analysis of growth factors (TGF-β, SCF-1, Ang-1, FGF-2, FGF-7, LIF, CTGF, VEGF, HGF, PDGF, and IGF-1) and b chemokines (MCP-1, CXCL12, CSF-1, TIMP-1, TIMP-2, Collagen III, Collagen IV, MMP2, and MMP9) in the myocardial infarcted zone of different groups relative to GAPDH. Data are shown as the mean ± SEM of triplicate wells in three different experiments. *: changed significantly than the PBS group, p < 0.05. #: changed significantly than the Nestin+ group, p < 0.05. c Structural and functional parameters derived from echocardiography measurements at 1 and 4 weeks with or without neutralizing antibody treatment. The means ± SEMs of the results are shown. ***: changed significantly than control group, p < 0.001; **p < 0.01; *p < 0.05. ##: changed significantly than Nestin+ BMSC group, p < 0.01; ###, p < 0.001; #, p < 0.05

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