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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

Fig. 6

Transcriptome analysis of breast cancer cells treated with adipocyte exosomes. a Heat map showed differentially expressed genes in adipocyte exosome-treated MCF7 and control MCF7. b–e Upregulation of cancer phenotype-associated genes in adipocyte exosome-treated MCF7. b Genes associated with cell proliferation. c Genes associated with programmed cell death. d Genes associated with migration. e Genes associated with angiogenesis. f Top 20 signaling pathways enriched in adipocyte exosome-treated MCF7. g–j qRT-PCR confirmed the increased expression of selected genes associated with cell cycle (G, CCND1, CCND3), cell proliferation (h, MET, MYC), migration (i, TGFB1, MMP9), and angiogenesis (j, VEGFA, HIF1A)

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Stem Cell Research & Therapy

ISSN: 1757-6512