F-box protein | Substrates | Cancer types | Functions | References |
---|---|---|---|---|
β-TrCP | Snail, β-catenin, Twist | Breast cancer, lung cancer, nasopharyngeal carcinoma, and cervical cancer | Oncoprotein or tumor suppressor; inhibits EMT, migration, and invasion | |
FBXW7 | Snail, MMPs, mTOR, RhoA | Lung cancer, gastric cancer, renal cell carcinoma, colorectal cancer, liver cancer, and cholangiocarcinoma | Tumor suppressor; inhibits EMT, invasion, and metastasis; and increases sensitivity to chemotherapeutic drugs | |
SKP2 | p27, Twist | Melanoma, breast cancer, osteosarcoma, and prostate cancer | Oncoprotein; promotes cell growth, EMT, and invasion; and increases drug resistance | |
FBXL5 | Snail1 | Gastric cancer and cervical cancer | Tumor suppressor; inhibits EMT and metastasis | |
FBXL14 | Snail1, Slug, Twist, Sip1 | Head and neck cancer | Tumor suppressor; inhibits EMT and metastasis | |
FBXO2 | None | Gastric cancer | Oncoprotein; promotes proliferation, metastasis, and EMT | [127] |
FBXO11 | Snail | Breast cancer and gastric cancer | Tumor suppressor; inhibits cell growth, EMT, and metastasis; induces apoptosis | |
FBXO22 | Snail | Breast cancer | Tumor suppressor; inhibits EMT and metastasis | [131] |
FBXO31 | Snail1 | Gastric cancer | Tumor suppressor; inhibits cell growth and EMT | [135] |
FBXO32 | MyoD, CtBP1 | Urothelial carcinoma and breast cancer | Induces apoptosis and inhibits EMT in urothelial carcinoma; promotes EMT and metastasis in breast cancer cells | |
FBXO45 | Snail1, Snail2, Twist1, ZEB1, ZEB2 | Prostate cancer, breast cancer, lung cancer, liver cancer, cervical cancer, and pancreatic cancer | Tumor suppressor or oncoprotein; inhibits EMT |