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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

Fig. 3

SCI mice treated with BMMSC-IGF1 demonstrate elevated progenitor cell presence, 5 days following SCI and transplant. Injured spinal cord section from BMMSC-IGF1-treated mouse immunostained for a DCX (red; scale bar = 10 μm), b double immunostained for DCX and PCNA (green; scale bar = 10 μm), and c detailed region with DCX (red; scale bar = 100 μm). Quantitative analysis of d DCX-positive cells and e percentage of IBA1 cells from injured spinal cords. RT-qPCR analysis of expression of f Mbp, g Olig1, h Olig2, and i NKx2.2, genes associated with oligodendrocyte progenitor cells differentiation. Values represent mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001

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