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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury

Fig. 2

Importance of EVs as vehicles for genetic communication between stem cells and injured renal cells during AKI. By delivering mRNAs and miRNAs, SC-EVs may activate regenerative programs in injured renal cells and stimulate them to dedifferentiate into normal renal cells. Alternatively, EVs originating from injured renal cells also contain genetic information that is believed to be able to influence the phenotypic and functional changes of stem cells, favoring renal recovery. SC-EVs, stem cells derived EVs; EVs, extracellular vesicles

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Stem Cell Research & Therapy

ISSN: 1757-6512