Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury

Table 2 Evidence demonstrating the existence of horizontal mRNA transfer from SC-EVs to injured renal cells in AKI

References	Year	Sample	AKI model	EVs type	Stem cells source	Outcomes
Bruno [13]	2009	Mice	Glycerol	MVs	MSCs	↑Transfer of mRNA, ↑cell proliferation, ↓apoptosis, ↑renal function
Bruno [55]	2012	Mice	Cisplatin	MVs	MSCs	↑Transfer of mRNA, ↓apoptosis, ↑renal function
Tomasoni [56]	2013	PTECs	Cisplatin	Exosomes	MSCs	↑Transfer of IGF-1R mRNA, ↑cell proliferation
Ju [57]	2015	Rats	I/R	MVs	MSCs	↑Transfer of HGF mRNA, ↑HGF, ↓α-SMA, ↑cell proliferation and dedifferentiation, ↓apoptosis, ↑renal function

SC-EVs stem cell-derived extracellular vesicles, AKI acute kidney injury, EVs extracellular vesicles, MVs microvesicles, MSCs mesenchymal stem cells, PTECs proximal tubular epithelial cells, IGF-1R insulin-like growth factor-1 receptor, I/R ischemia/reperfusion, HGF hepatocyte growth factor

ISSN: 1757-6512