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Table 3 Evidence demonstrating the existence of horizontal transfer of miRNA from SC-EVs to injured renal cells in AKI

From: Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury

References

Year

Sample

AKI model

EVs type

Stem cells source

Outcomes

Lindoso [48]

2014

PTECs

I/R

EVs

MSCs

↑Transfer of miR-148b-3p, miR-410, miR-495, and miR-548c-5p, ↑cell viability

Vinas [61]

2016

Mice

I/R

Exosomes

ECFCs

↑Transfer of miR-486-5p, ↓PTEN, ↑Akt phosphorylation, ↓apoptosis, ↑renal function

Gu [62]

2016

Rats

I/R

EVs

WJMSCs

↑Transfer of miR-30, ↓DRP-1, ↓mitochondrial fragmentation, ↓apoptosis, ↑renal function

  1. SC-EVs stem cell-derived extracellular vesicles, AKI acute kidney injury, EVs extracellular vesicles, PTECs proximal tubular epithelial cells, I/R ischemia/reperfusion, MSCs mesenchymal stem cells, ECFCs endothelial colony-forming cells, PTEN phosphatase and tensin homolog, WJMSCs Wharton’s Jelly mesenchymal stromal cells, DRP-1 dynamin-related protein-1
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Stem Cell Research & Therapy

ISSN: 1757-6512