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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: microRNA-301b-3p downregulation underlies a novel inhibitory role of long non-coding RNA MBNL1-AS1 in non-small cell lung cancer

Fig. 5

miR-301b-3p reverses the suppressive effects of lncRNA MBNL1-AS1 on A549-SP+. a Proliferation of A549-SP+ after lncRNA MBNL1-AS1 and miR-301b-3p overexpression detected using CCK-8. b Drug resistance of A549-SP+ against anti-tumor drugs after lncRNA MBNL1-AS1 and miR-301b-3p overexpression detected using CCK-8. c Clone formation of A549-SP+ detected after lncRNA MBNL1-AS1 and miR-301b-3p overexpression using clone formation assay. d Cell invasion of A549-SP+ after lncRNA MBNL1-AS1 and miR-301b-3p overexpression detected using transwell assay. e Cell migration of A549-SP+ after lncRNA MBNL1-AS1 and miR-301b-3p overexpression detected using scratch test. f Sphere formation of A549-SP+ after lncRNA MBNL1-AS1 and miR-301b-3p overexpression detected using sphere formation assay. g Protein levels of Oct4, ABCG2 in A549-SP+ after lncRNA MBNL1-AS1, and miR-301b-3p overexpression assessed using western blot analysis; *p < 0.05 vs. A549 cells treated with oe-NC. Measurement data were depicted as mean ± standard deviation. Comparisons among multiple groups analyzed using one-way ANOVA with Tukey post hoc test used. The experiment was repeated three times

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