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Table 1 Main cardiac parameters calculated from magnetic resonance exams performed throughout the study

From: Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells

Groups CON (vehicle) 25 M (25 × 106 pCPC) 50 M (50 × 106 pCPC)
Day 7 (healthy) Day 0 (preinjection) 1 week 10 weeks Day 7 (healthy) Day 0 (preinjection) 1 week 10 weeks Day 7 (healthy) Day 0 (preinjection) 1 week 10 weeks
LVEF (%) 54.9 ± 11.2 38.0 ± 9.6 40.4 ± 5.4 42.1 ± 10.0 52.5 ± 6.4 41.7 ± 8.1 42.8 ± 7.6 46.5 ± 7.4 52.0 ± 6.2 40.1 ± 6.5 43.7 ± 6.5 50.2 ± 4.9*
EDVi (mL/m2) 80.0 ± 18.4 105.0 ± 10.6 111.7 ± 11.2 119.0 ± 24.8 80.1 ± 11.7 97.2 ± 9.7 108.6 ± 15.3 104.3 ± 14.2 84.1 ± 10.1 94.8 ± 14.7 97.5 ± 17.6 94.0 ± 11.4**
ESVi (mL/m2) 36.5 ± 12.7 65.4 ± 14.5 66.7 ± 10.5 70.5 ± 25.5 38.3 ± 8.5 56.7 ± 9.2 62.8 ± 15.3 56.3 ± 14.0 40.4 ± 7.3 56.7 ± 11.9 56.2 ± 17.8 47.0 ± 8.2**
Infarct (%) n/a 16.7 ± 5.1 11.3 ± 2.7 8.3 ± 2.8* n/a 14.6 ± 6.1 11.0 ± 6.7 8.7 ± 5.2 n/a 13.4 ± 5.3 11.0 ± 5.4 5.9 ± 4.1*
edema (%) n/a 23.4 ± 5.9 18.7 ± 4.4 6.7 ± 1.1 n/a 25.2 ± 6.6 14.2 ± 5.4 6.7 ± 3.9 n/a 27.3 ± 8.4 15.0 ± 4.2 5.3 ± 3.6
  1. Data presented as mean ± standard deviation. Infarct area is expressed as % of the left ventricle. Edema was calculated at a mid-heart slice and expressed as % of this slice
  2. LVEF left ventricular ejection fraction, EDVi end-diastolic volume indexed to body surface area, ESVi end-systolic volume indexed to body surface area, n/a not applicable
  3. *p < 0.05 compared to preinjection (day 0) values within groups
  4. **p < 0.05 compared to CON at the same time point