|
Groups
|
CON (vehicle)
|
25 M (25 × 106 pCPC)
|
50 M (50 × 106 pCPC)
|
|---|
|
Day 7 (healthy)
|
Day 0 (preinjection)
|
1 week
|
10 weeks
|
Day 7 (healthy)
|
Day 0 (preinjection)
|
1 week
|
10 weeks
|
Day 7 (healthy)
|
Day 0 (preinjection)
|
1 week
|
10 weeks
|
|---|
|
LVEF (%)
|
54.9 ± 11.2
|
38.0 ± 9.6
|
40.4 ± 5.4
|
42.1 ± 10.0
|
52.5 ± 6.4
|
41.7 ± 8.1
|
42.8 ± 7.6
|
46.5 ± 7.4
|
52.0 ± 6.2
|
40.1 ± 6.5
|
43.7 ± 6.5
|
50.2 ± 4.9*
|
|
EDVi (mL/m2)
|
80.0 ± 18.4
|
105.0 ± 10.6
|
111.7 ± 11.2
|
119.0 ± 24.8
|
80.1 ± 11.7
|
97.2 ± 9.7
|
108.6 ± 15.3
|
104.3 ± 14.2
|
84.1 ± 10.1
|
94.8 ± 14.7
|
97.5 ± 17.6
|
94.0 ± 11.4**
|
|
ESVi (mL/m2)
|
36.5 ± 12.7
|
65.4 ± 14.5
|
66.7 ± 10.5
|
70.5 ± 25.5
|
38.3 ± 8.5
|
56.7 ± 9.2
|
62.8 ± 15.3
|
56.3 ± 14.0
|
40.4 ± 7.3
|
56.7 ± 11.9
|
56.2 ± 17.8
|
47.0 ± 8.2**
|
|
Infarct (%)
|
n/a
|
16.7 ± 5.1
|
11.3 ± 2.7
|
8.3 ± 2.8*
|
n/a
|
14.6 ± 6.1
|
11.0 ± 6.7
|
8.7 ± 5.2
|
n/a
|
13.4 ± 5.3
|
11.0 ± 5.4
|
5.9 ± 4.1*
|
|
edema (%)
|
n/a
|
23.4 ± 5.9
|
18.7 ± 4.4
|
6.7 ± 1.1
|
n/a
|
25.2 ± 6.6
|
14.2 ± 5.4
|
6.7 ± 3.9
|
n/a
|
27.3 ± 8.4
|
15.0 ± 4.2
|
5.3 ± 3.6
|
- Data presented as mean ± standard deviation. Infarct area is expressed as % of the left ventricle. Edema was calculated at a mid-heart slice and expressed as % of this slice
- LVEF left ventricular ejection fraction, EDVi end-diastolic volume indexed to body surface area, ESVi end-systolic volume indexed to body surface area, n/a not applicable
- *p < 0.05 compared to preinjection (day 0) values within groups
- **p < 0.05 compared to CON at the same time point
