Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells

Table 1 Main cardiac parameters calculated from magnetic resonance exams performed throughout the study

Groups	CON (vehicle)				25 M (25 × 10⁶ pCPC)				50 M (50 × 10⁶ pCPC)
Groups	Day 7 (healthy)	Day 0 (preinjection)	1 week	10 weeks	Day 7 (healthy)	Day 0 (preinjection)	1 week	10 weeks	Day 7 (healthy)	Day 0 (preinjection)	1 week	10 weeks
LVEF (%)	54.9 ± 11.2	38.0 ± 9.6	40.4 ± 5.4	42.1 ± 10.0	52.5 ± 6.4	41.7 ± 8.1	42.8 ± 7.6	46.5 ± 7.4	52.0 ± 6.2	40.1 ± 6.5	43.7 ± 6.5	50.2 ± 4.9*
EDVi (mL/m²)	80.0 ± 18.4	105.0 ± 10.6	111.7 ± 11.2	119.0 ± 24.8	80.1 ± 11.7	97.2 ± 9.7	108.6 ± 15.3	104.3 ± 14.2	84.1 ± 10.1	94.8 ± 14.7	97.5 ± 17.6	94.0 ± 11.4**
ESVi (mL/m²)	36.5 ± 12.7	65.4 ± 14.5	66.7 ± 10.5	70.5 ± 25.5	38.3 ± 8.5	56.7 ± 9.2	62.8 ± 15.3	56.3 ± 14.0	40.4 ± 7.3	56.7 ± 11.9	56.2 ± 17.8	47.0 ± 8.2**
Infarct (%)	n/a	16.7 ± 5.1	11.3 ± 2.7	8.3 ± 2.8*	n/a	14.6 ± 6.1	11.0 ± 6.7	8.7 ± 5.2	n/a	13.4 ± 5.3	11.0 ± 5.4	5.9 ± 4.1*
edema (%)	n/a	23.4 ± 5.9	18.7 ± 4.4	6.7 ± 1.1	n/a	25.2 ± 6.6	14.2 ± 5.4	6.7 ± 3.9	n/a	27.3 ± 8.4	15.0 ± 4.2	5.3 ± 3.6

Data presented as mean ± standard deviation. Infarct area is expressed as % of the left ventricle. Edema was calculated at a mid-heart slice and expressed as % of this slice
LVEF left ventricular ejection fraction, EDVi end-diastolic volume indexed to body surface area, ESVi end-systolic volume indexed to body surface area, n/a not applicable
*p < 0.05 compared to preinjection (day 0) values within groups
**p < 0.05 compared to CON at the same time point

ISSN: 1757-6512