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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Fig. 3

Epigenetic regulations mediated by MenSCs in vivo. a Schematic diagram of the treatment with MenSCs that carried luciferase and serum-free medium in nude mice bearing xenograft HCC cells. b IHC assay displayed the distribution of MenSCs in HCC tissues. c Comparison of tumor volume between the MenSC group and control group during the period of MenSC implantation. d Comparison of tumor weight between two groups after three times of MenSC implantation. e IHC assay showed alterations in 5-hmC, Ki67, TETs, and DNMTs in HCC tissues with MenSC therapy. Scale bar 100 μm. *P < 0.05, ***P < 0.001

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