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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Fig. 4

Landscapes of 5-hmC and 5-mC in HCC cells after MenSC therapy. a 5-hmC and 5-mC distribution in different genomic regions including promoter, gene body, and intergenic regions. b Distribution of 5-hmC and 5-mC in the 5-kb upstream and downstream flanking regions of the TSS in HCC cells with or without MenSC treatment. c Distribution of DHMRs and DMRs in all chromosomes in HCC cells after MenSC therapy. d Top pathways of DHMRs and DMRs in enhancer regions. The dot plot shows the gene ratio values of the top ten most significantly enriched pathways; the dot size indicates the number of corresponding genes, and the color shows the P value

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