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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Fig. 7

MenSCs induce differential expressed genes associated with 5-hmC and 5-mC changes. a Hierarchical clustering of RNA-seq results across 6 HCC cell samples. b Volcano plot analysis showed differentially expressed genes between HCC cells with or without MenSCs coculture. c Significantly changed genes among three groups from RNA-seq, MeDIP-seq, and hMeDIP-seq data of HCC cells. d Expression level of ACSS1, HMGA1, and BYSL in HCC tissues and normal tissues from TCGA database. e Expression of ACSS1, HMGA1, and BYSL were associated with overall survival of HCC patients by Kaplan-Meier from TCGA database

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