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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation

Fig. 2

Analysis of global DNA methylation profile. a Multidimensional scaling plot of donor (P0) and patient samples (Pn); assessment and elimination of confounding factors: (i) segregation of patients due to sex (elimination of probes on sex chromosomes), (ii) segregation of P19 cluster (t0-t5) from all other samples (elimination of P19 samples), (iii) segregation of P2 t4 from all other samples (elimination of P2 t4), (iv) no other confounding factors found. b Unsupervised hierarchical clustering of global methylation profile on the most variable probes; for each sample, the figure indicated patient number (P), donor age (D years) and recipient age (R years), disease (AML or ALL), and respective time points (t0 or t1-t5). Each patient with its donor was annotated with a specific color. c Global DNA methylation profile (M value) in grouped donors (t0) and patients in all time points (t1, t2, t3, t4, t5). d Global DNA methylation profile (M value) of promoter (yellow) and gene body (orange) regions in grouped donors (t0) and patients in all time points (t1, t2, t3, t4, t5). Horizontal bar indicated the median of methylation

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