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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation

Fig. 3

Differential methylation profile between donor and recipient HSPCs. a Heatmap of significant DMPs common in all comparisons between donors (t0) and recipients (t1-t5). Differential methylation was annotated by different colors (green hypo-methylation and red hyper-methylation, respectively). In the lower part of the heatmap, the numbers indicated the different time points. b Number of DMPs in all recipient time points (t1-t5) vs donors (t0) distinct in hypo- and hyper-methylated probes. c Number of DMRs in all recipient time points (t1-t5) vs donors (t0) distinct in hypo- and hyper-methylated regions. d Distribution of hyper- and hypo-methylated probes across CpG sites (Island, Open Sea, Shelf, and Shore) in promoter and body regions in all time points compared to t0. In the vertical bar are reported the number of hyper-methylated (0 to 4000) and hypo-methylated (0 to − 2000) DMPs

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