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Table 2 GRADE evidence profile for the outcomes

From: Autologous stem cell therapy for peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials

Certainty assessment No. of patients Effect Quality of evidence Importance
No. of studies Study design Risk of bias Inconsistency Indirectness Imprecision Publication bias Stem cell therapy Control (95% CI)
ABI
 16 RCT No serious limitations Serious limitations No serious limitations No serious limitations Yes 396 443 MD 0.13 (0.10, 0.17) Important
TcO2
 8 RCT No serious limitations Serious limitations No serious limitations No serious limitations No 217 258 MD 12.62 (5.73, 19.51) Important
Major amputation rate
 8 RCT No serious limitations No serious limitations No serious limitations Serious limitations Yes 49/232 (21.1%) 60/197 (305%) OR 0.66 (0.42, 1.03) Key
Amputation rate
 16 RCT No serious limitations No serious limitations No serious limitations Serious limitations Yes 88/425 (20.7%) 142/444 (32.0%) OR 0.50 [0.36, 0.69] Key
Ulcer healing rate
 14 RCT No serious limitations No serious limitations No serious limitations Serious limitations No 170/313 (54.3%) 90/310 (29.0%) OR 4.31 [2.94, 6.30] Key
Rest pain score
 9 RCT No serious limitations Serious limitations No serious limitations No serious limitations No 260 298 MD − 1.61 [− 2.01, − 1.21] Important
Pain-free walking distance
 3 RCT No serious limitations No serious limitations No serious limitations Serious limitations No 48 49 MD 178.25 [128.18, 228.31] Important